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Risperidone mesylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Risperidone mesylate图片
CAS NO:666179-96-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
R 64 766 mesylate
产品介绍
Risperidone mesylate(R 64 766 mesylate) 是5-HT2受体的阻断剂,P-糖蛋白(P-Glycoprotein)的抑制剂 和dopamine D2受体的拮抗剂,其对 5-HT2A和 dopamine D2受体的Ki值分别为 4.8,5.9 nM。
生物活性

Risperidone mesylate(R 64 766 mesylate) is a serotonin5-HT2receptorblocker,P-Glycoproteininhibitor and potentdopamineD2receptorantagonist, withKisof 4.8, 5.9 nM for 5-HT2Aand dopamineD2receptor, respectively.

IC50& Target

5-HT2AReceptor

4.8 nM (Ki)

D2Receptor

5.9 nM (Ki)

P-glycoprotein

 

体外研究
(In Vitro)

Risperidone is a serotonin 5-HT2receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2Aand dopamine D2receptor, respectively. Risperidone dose-dependently inhibited the release of IL-12 in mature DCs, while the production of IL-10 is dose-dependently increased by Risperidone. A high dose of risperidone can induce TNF-α release from mature DCs[3].

体内研究
(In Vivo)

In the first experiment, body weight is found to be slightly but significantly lower in the Risperidone-treated rats as a function of age. Similar to the first experiment, age-dependent differences in body weight are also observed between the three treatment groups in the second locomotor experiment. Rats treated with the 3.0 mg/kg dose of Risperidone weigh less than vehicle-treated rats on postnatal days 35, 38, and 41. The third locomotor experiment involves larger, mixed-sex litters in contrast to the smaller, single-sex litters used in the first two experiments. As noted for the first two experiments, rats treated with Risperidone in the third experiment gain less weight in an age-dependent manner[4].

Clinical Trial
分子量

506.59

Formula

C24H31FN4O5S

CAS 号

666179-96-0

中文名称

利哌酮甲磺酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.