CAS NO: | 87134-87-0 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selectivedopamine D1-like receptorantagonist withKis of 0.2 nM and 0.3 nM for theD1andD5receptor, respectively. SCH-23390 maleate is a potent and high efficacyhuman 5-HT2Creceptoragonist with aKiof 9.3 nM. SCH-23390 maleate also binds with high affinity to the5-HT2and5-HT1Creceptors. SCH-23390 maleate inhibitsG protein-coupled inwardly rectifying potassium (GIRK) channelswith anIC50of 268 nM[1][2][3]. | ||||
IC50& Target[1][2][3] |
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体外研究 (In Vitro) | SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway[4]. | ||||
体内研究 (In Vivo) | SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants: pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D1receptors in rodents, nonhuman primates, and humans[1]. | ||||
分子量 | 403.86 | ||||
Formula | C21H22ClNO5 | ||||
CAS 号 | 87134-87-0 | ||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |