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Mosapride citrate dihydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mosapride citrate dihydrate图片
CAS NO:636582-62-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
TAK-370 citrate dihydrate
AS-4370 citrate dihydrate
产品介绍
Mosapride (TAK-370) citrate dehydrate 是一种胃促动力剂,具有5-羟色胺4受体(5-hydroxytryptamine4)激动剂活性,已广泛用于研究多种胃肠道疾病。Mosapride citrate dehydrate 对Kv4.3具有浓度依赖的抑制作用,其IC50值为 15.2 μM。Mosapride citrate dehydrate 在体内实验中也有选择性地刺激上消化道运动。
生物活性

Mosapride (TAK-370) citrate dehydrate is a gastroprokinetic agent with5-hydroxytryptamine4receptor agonist activity and has been widely used in the research of a variety of gastrointestinal disorders. Mosapride citrate dihydrate potently inhibitsKv4.3in a concentration-dependent manner withIC50values of 15.2 μM[1]. Mosapride citrate dihydrateselectively stimulates upper GI motility in vivo[2].

IC50& Target

5-HT4Receptor

 

Kv4.3

15.2 μM (IC50)

体外研究
(In Vitro)

Mosapride (0.3-30 μM) exhibits an inhibitory activity against Kv4.3 with an IC50of 15.2 μM in a concentration-dependent manner. Mosapride also inhibits the open state of Kv4.3 currents during depolarization and accelerates the closed-state inactivation at subthreshold potentials[1].

体内研究
(In Vivo)

Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility[2].

Animal Model:Beagle dogs[2]
Dosage:0.3-3 mg/kg
Administration:Intravenous injection; 0.3-3 mg/kg
Result:Increased the antral motor activity dose-dependently in conscious dogs.
Clinical Trial
分子量

650.05

Formula

C27H37ClFN3O12

CAS 号

636582-62-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.