Mosapride (TAK-370) citrate dehydrate is a gastroprokinetic agent with5-hydroxytryptamine₄receptor agonist activity and has been widely used in the research of a variety of gastrointestinal disorders. Mosapride citrate dihydrate potently inhibitsKv4.3in a concentration-dependent manner withIC₅₀values of 15.2 μM^[1]. Mosapride citrate dihydrateselectively stimulates upper GI motility in vivo^[2].

Mosapride (0.3-30 μM) exhibits an inhibitory activity against Kv4.3 with an IC₅₀of 15.2 μM in a concentration-dependent manner. Mosapride also inhibits the open state of Kv4.3 currents during depolarization and accelerates the closed-state inactivation at subthreshold potentials^[1].

Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility^[2].

650.05

C₂₇H₃₇ClFN₃O₁₂

636582-62-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.