CAS NO: | 1052147-86-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | LP-211 is a selective and blood–brain barrier penetrant5-HT7receptoragonist, with aKiof 0.58 nM, with high selectivity over 5-HT1Areceptor (Ki, 188 nM) andD2receptor(Ki, 142 nM). | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | LP-211 is a selective 5-HT7receptor agonist, with a Kiof 0.58 nM, 324- and 245-fold selectivity over 5-HT1Areceptor (Ki, 188 nM) and D2receptor (Ki, 142 nM). LP-211 shows agonist properties with an EC50of 0.6 μM[1]. | ||||||||||||||||
体内研究 (In Vivo) | LP-211 (10 mg/kg, i.p.) rapidly reaches the systemic circulation in the mouse, with mean Cmaxof 0.76 ± 0.32 μg/mL at 30 min[1]. LP-211 (0.003-0.3 mg/kg, i.p.) significantly increases the micturition volume in a dose-dependent manner, and causes significant increases in voiding efficiency in spinal cord-injured (SCI) rats, and such effects can be completely reversed by SB-269970[2]. LP-211 (0.25 and 0.50 mg/kg i.p.) improves consolidation of chamber-shape memory in rats, resulting in significant novelty-induced hyperactivity and recognition[3]. | ||||||||||||||||
分子量 | 466.62 | ||||||||||||||||
性状 | Oil | ||||||||||||||||
Formula | C30H34N4O | ||||||||||||||||
CAS 号 | 1052147-86-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(214.31 mM;Need ultrasonic) Ethanol : 50 mg/mL(107.15 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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