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Thienyldecyl Isothiocyanate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Thienyldecyl Isothiocyanate图片
CAS NO:288323-41-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Cas No.288323-41-1
化学名2-(10-isothiocyanatodecyl)-thiophene
Canonical SMILESS=C=NCCCCCCCCCCC1=CC=CS1
分子式C15H23NS2
分子量281.5
溶解度≤30mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thienyldecyl isothiocyanate is a cytochrome P450 inhibitor [1].

The human cytochrome P450 (CYP), a cellular chromophore, has been implicated in metabolism of drugs, arachidonic acid, foreign chemicals, and eicosanoids; steroid synthesis and metabolism; vitamin D3 synthesis and metabolism; cholesterol metabolism and bile-acid biosynthesis; retinoic acid hydroxylation. Until now, there are more than 270 different CYP gene families have been identified, with 18 recorded in mammals. It has been repoted that cytochrome P450 is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes result in inborn errors of metabolism and contribute to many clinically relevant diseases [2].

Thienyldecyl isothiocyanate was an analog of thienylbutyl isothiocyanate. Thienyldecyl isothiocyanate showed antiproliferative activity against cancer cells presumably that, like many isothiocyanates. Thienyldecyl isothiocyanate functioned by modulation of xenobiotic-metabolizing enzymes, such as by inhibition of cytochrome P450, and/or by induction of phase II detoxifying enzymes [1].

References:
[1] Yu R, Mandlekar S, Harvey K J, et al.  Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity[J]. Cancer Research, 1998, 58(3): 402-408.
[2] Nebert D W, Russell D W.  Clinical importance of the cytochromes P450[J]. The Lancet, 2002, 360(9340): 1155-1162.