GR-46611

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GR-46611

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

185259-85-2

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议

产品介绍

GR-46611 是一种5-HT_1D受体激动剂。GR-46611 可用于膀胱多动症、白血病的研究。

生物活性

GR-46611 is a5-HT_1Dreceptoragonist. GR-46611 can be used in the research of bladder hyperactivity, leukemia^[1]^[3].

IC₅₀& Target^[1]

5-HT_1DReceptor

体外研究
(In Vitro)

GR-46611 (1 μM, 48 h) induces CEM cell proliferation^[2].

Cell Proliferation Assay^[2]

Cell Line:	CEM cells (human T lymphoblastic leukemia cell line)
Concentration:	1 μM
Incubation Time:	48 h
Result:	Induced a significant increase in cell proliferation by 37.0%.

体内研究
(In Vivo)

GR-46611 (1 mg/kg, i.p. ) significantly improves survival of Dravet syndrome (DS) mice^[1].
GR-46611 (0.03-300 μg/kg, i.v.) increases threshold volume, bladder capacity, and residual volume in chronic spinal cord injury (SCI) cats^[3].
GR46611 (3-30 mg/kg, s.c.) causes a dose-related decrease in rectal temperature in the adult guinea-pig^[4].

Animal Model:	Dravet syndrome (DS) mice^[1]
Dosage:	0.01, 0.1 and 1 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Improved survival relative to vehicle treated controls with 89% surviving rate.

分子量

377.48

性状

Solid

Formula

C₂₃H₂₇N₃O₂

CAS 号

185259-85-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(264.91 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.6491 mL	13.2457 mL	26.4915 mL
5 mM	0.5298 mL	2.6491 mL	5.2983 mL
10 mM	0.2649 mL	1.3246 mL	2.6491 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。