SIRT2-IN-11

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SIRT2-IN-11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1005095-06-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

SIRT2-IN-11 (AEM1) 是选择性的SIRT2抑制剂，IC₅₀值为 18.5 μM。SIRT2-IN-11 以 p53 依赖的诱导细胞凋亡，激活CDKN1A，PUMA和NOXA的表达，并且促进 p53 的乙酰化。SIRT2-IN-11 可用于 p53 相关的癌症研究。

生物活性

SIRT2-IN-11 (AEM1) is a selectiveSIRT2inhibitor with anIC₅₀value of 18.5 μM. SIRT2-IN-11 p53-dependently inducesapoptosis, activates expression ofCDKN1A,PUMAandNOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers^[1].

IC₅₀& Target

SIRT2

18.5 μM (IC₅₀)

SIRT1

118.4 μM (IC₅₀)

体外研究
(In Vitro)

SIRT2-IN-11 (0-1000 μM) shows inhibitory effect of SIRT2-dependent deacetylation of MAL with an IC₅₀value of 18.5 μM^[1].
SIRT2-IN-11 (0-1000 μM) weakly inhibits SIRT1 with an IC₅₀value of 118.4 μM^[1].
SIRT2-IN-11 (0-20 μM; 8 h) induces cell apoptosis of lung cancer cells^[1].
SIRT2-IN-11 (20 μM; 6 h) increases p53 acetylation and expression levels of Cp53 target genesCDKN1A,PUMAandNOXA^[1].

RT-PCR^[1]

Cell Line:	NSCLC cell lines
Concentration:	20 μM
Incubation Time:	6 hours
Result:	Increased the expression of CDKN1A, PUMA and NOXA.

Apoptosis Analysis^[1]

Cell Line:	A549 cell line
Concentration:	0, 0.5, 1, 5, 10 and 20 μM
Incubation Time:	24 hours
Result:	Mildly increased apoptosis of A549 cells, but when combined treatment with etoposide caused a marked increase in apoptosis.

分子量

318.41

Formula

C₂₁H₂₂N₂O

CAS 号

1005095-06-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.