PS432 is aPKCinhibitor withIC₅₀s of 16.9 μM (PKC_ι) and 18.5 μM (PKC_ζ), respectively. PS432 effectively inhibits the proliferation of non-small cell lungcancercells (NSCLCs) and tumor growth in mouse xenograft models^[1].

PS432 (25 μM; 24 h) 抑制癌细胞增殖，例如抑制 A549 和 A427 的 IC₅₀为 14.8 μM 和 10.4 μM^[1]。
PS432 (50 μM; 12, 24, 36 h) 将 A549 肺癌细胞的细胞周期阻滞在 G0/G1 期^[1]。

PS432 (2.5 mg/kg; 腹腔注射; 每天 1 次, 共 14 天) 在肺癌异种移植模型中抑制肿瘤生长^[1]。

494.95

C₂₅H₁₉ClN₂O₅S

2083630-26-4

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