CAS NO: | 145333-02-4 |
包装: | 1mg |
生物活性 | Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally activePKCinhibitor withIC50s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM forPKCα,PKCβI,PKCβII,PKCγ, andPKCε, respectively[1][2]. | |||||
IC50& Target[1] |
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体外研究 (In Vitro) | Bisindolylmaleimide XI hydrochloride (Ro 32-0432) inhibits IL-2 secretion, IL-2 receptor expression in, and proliferation of, peripheral human T-cells stimulated with phorbol ester together with phytohemagglutin or anti-CD3, but does not inhibit IL-2 induced proliferation in cells already stimulated to express IL-2 receptors. Proliferation of the influenza peptide antigen HA 307-319-specific human T-cell clone (HA27) after exposure to antigen-pulsed autologous presenting cells is also inhibited by Bisindolylmaleimide XI hydrochloride[2]. | |||||
体内研究 (In Vivo) | Oral administration of Bisindolylmaleimide XI hydrochloride inhibits subsequent phorbol ester-induced edema in ratss. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Bisindolylmaleimide XI hydrochloride[2]. | |||||
分子量 | 489.01 | |||||
性状 | Solid | |||||
Formula | C28H29ClN4O2 | |||||
CAS 号 | 145333-02-4 | |||||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||||
储存方式 | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |