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Bisindolylmaleimide XI hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bisindolylmaleimide XI hydrochloride图片
CAS NO:145333-02-4
包装:1mg

产品名称
Ro 32-0432
Ro 31-8830 hydrochloride
产品介绍
Bisindolylmaleimide XI hydrochloride (Ro 32-0432) 是一种有效、选择性和具有口服活性的PKC抑制剂,对PKCαPKCβIPKCβIIPKCγIC50分别为 9 nM、28 nM、31 nM、37 nM 和 108 nM。
生物活性

Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally activePKCinhibitor withIC50s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM forPKCα,PKCβI,PKCβII,PKCγ, andPKCε, respectively[1][2].

IC50& Target[1]

PKC-α

9 nM (IC50)

PKC-βI

28 nM (IC50)

PKC-βII

31 nM (IC50)

PKC-γ

37 nM (IC50)

PKC-ε

108 nM (IC50)

体外研究
(In Vitro)

Bisindolylmaleimide XI hydrochloride (Ro 32-0432) inhibits IL-2 secretion, IL-2 receptor expression in, and proliferation of, peripheral human T-cells stimulated with phorbol ester together with phytohemagglutin or anti-CD3, but does not inhibit IL-2 induced proliferation in cells already stimulated to express IL-2 receptors. Proliferation of the influenza peptide antigen HA 307-319-specific human T-cell clone (HA27) after exposure to antigen-pulsed autologous presenting cells is also inhibited by Bisindolylmaleimide XI hydrochloride[2].
PKC inhibition with Bisindolylmaleimide XI hydrochloride (Ro 32-0432; 1 μM) decreases the proportion of apoptotic cells (-21%) in retinal progenitor cells (RPCs)[3].

体内研究
(In Vivo)

Oral administration of Bisindolylmaleimide XI hydrochloride inhibits subsequent phorbol ester-induced edema in ratss. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Bisindolylmaleimide XI hydrochloride[2].

分子量

489.01

性状

Solid

Formula

C28H29ClN4O2

CAS 号

145333-02-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)