CGP-53353

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CGP-53353

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

145915-60-2

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议

产品名称

DAPH-7

产品介绍

CGP-53353 (DAPH-7) 是一种有效的PKC抑制剂，对 PKCβII 和 PKCβI 的IC₅₀分别为 0.41 mM 和 3.8 mM。CGP-53353 能在 AoSMC 和 A10 细胞中抑制葡萄糖诱导的细胞增殖和 DNA 合成 (DNA synthesis)。CGP-53353 可用于糖尿病患者动脉粥样硬化的研究。

生物活性

CGP-53353 (DAPH-7) is an potentPKCinhibitor withIC₅₀s of 0.41 mM and 3.8 mM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation andDNA synthesisin AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients^[1].

IC₅₀& Target^[1]

PKCβII

0.41 mM (IC₅₀)

PKCβI

3.8 mM (IC₅₀)

体外研究
(In Vitro)

CGP-53353 (DAPH-7) (1 μM; 48-96 hours) inhibits glucose-induced cell proliferation in A10 cells^[1].
CGP-53353 (1 μM ; 0-48 hours) inhibits the glucose-induced increase and acceleration of DNA synthesis in A10, also blocks the glucose-induced increase of S-phase cell percentage^[1].

Cell Proliferation Assay

Cell Line:	A10 (cell proliferation induced by glucose)^[1]
Concentration:	1 μM
Incubation Time:	48-96 hours
Result:	Inhibited glucose-induced cell proliferation, although A10 cell proliferation was stimulated by increasing glucose concentrations.

分子量

365.33

性状

Solid

Formula

C₂₀H₁₃F₂N₃O₂

CAS 号

145915-60-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 50 mg/mL(136.86 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.7373 mL	13.6863 mL	27.3725 mL
5 mM	0.5475 mL	2.7373 mL	5.4745 mL
10 mM	0.2737 mL	1.3686 mL	2.7373 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。