EB-47, a potent and selectivePARP-1/ARTD-1inhibitor with anIC₅₀value of 45 nM, shows modest potency against ARTD5 with anIC₅₀value of 410 nM. EB-47 mimics the substrate NAD⁺ and extends from the nicotinamide to the adenosine subsite^[1].

EB-47 shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC₅₀values of 0.86 and 1.0 μM, respectively^[1].

EB-47 (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation^[3].

537.53

C₂₄H₂₇N₉O₆

366454-36-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.