DR2313 is a potent, selective, competitive and brain-penetrant inhibitor ofpoly(ADP-ribose) polymerase (PARP), withIC₅₀s of 0.20 μM and 0.24 μM forPARP-1andPARP-2, respectively. DR2313 exhibits neuroprotective effects on ischemic injuries in vitro and in vivo^[1][2].

DR2313 (0.016-16.4 μM; 30 min) inhibits poly(ADP-ribosyl)ation reaction in nuclear extracts of rat brain, with a K_iof 0.23 μM^[1].
DR2313 shows more powerful inhibition of the poly(ADP-ribosyl)ation in the nuclear extracts of the rat brain (IC₅₀=0.20 μM) than 3AB (35.4 μM), PND (0.56 μM), DIQ (2.96 μM), and DPQ (0.96 μM)^[1].
DR2313 (1-100 μM; 10 min) shows a weak inhibition of the mono(ADP-ribosyl)ation in a concentration-dependent manner (IC₅₀=59 μM)^[1].
DR2313 (0.1-30 μM; pretreated for 30 min) reduces hydrogen peroxide (500 μM; 4 h) or glutamate (1 mM; 30 min) induced excessive formation of poly(ADP-ribose) and cell death^[1].

DR2313 (3-10 mg/kg i.v. bolus or infusion for 6 h) significantly reduces the cortical infarct volume in both permanent and transient focal ischemia models in rats^[1].

182.24

Solid

C₈H₁₀N₂OS

284028-90-6

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

H₂O : ≥ 100 mg/mL(548.73 mM)

DMSO : 12.5 mg/mL(68.59 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

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储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。