NMS-P515

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NMS-P515

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1262395-13-0

包装与价格：

产品介绍

NMS-P515 是有效的、口服有效的、立体定向的PARP-1的抑制剂，K_d值为16 nM，IC₅₀值为 27 nM (Hela 细胞中)。有抗肿瘤活性。

生物活性

NMS-P515 is a potent, orally active and stereospecificPARP-1inhibitor, with aK_dof 16 nM and anIC₅₀of 27 nM (in Hela cells). Anti-tumor activity^[1].

IC₅₀& Target^[1]

PARP-1

16 nM (Kd)

PARP-1

27 nM (IC₅₀, in Hela cells)

体内研究
(In Vivo)

NMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse models based pancreatic cancer^[1].

Animal Model:	Subcutaneously implanted Capan-1 pancreatic (BRCA2-mutated) mouse xenografts^[1].
Dosage:	80 mg/kg.
Administration:	Orally, once daily for 12 days.
Result:	Clearly reduced the tumor growth (maximal tumor growth inhibition observed: 48%, maximum body weight loss: 6%).

分子量

355.47

Formula

C₂₁H₂₉N₃O₂

CAS 号

1262395-13-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.