SD-1029 是一种JAK2/STAT3抑制剂。SD-1029 抑制 STAT3 核易位。SD-1029 抑制 JAK2 磷酸化，从而抑制 STAT3 激活。
| 生物活性 | SD-1029 is aJAK2/STAT3inhibitor[1]. SD-1029 inhibitsSTAT3nuclear translocation. SD-1029 is an inhibitor ofSTAT3activation due to inhibition ofJAK2phosphorylation[2]. |
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体外研究
(In Vitro) | SD-1029 (10 μM) inhibits EGFP-Stat3 nuclear translocation in BHK-21 and U-2OS cells[1].
SD-1029 (5 and 10 μM; 24 hours) inhibits cell growth and induces apoptosis in OVCAR8TRovarian cancer cells[1].
SD-1029 (10 μM; 24 hours) suppresses p-Stat3 levels in human breast and ovarian cancer cell lines[1].
SD-1029 inhibits not only JAK2 phosphorylation, but also the phosphorylation of STAT1 and STAT3. SD-1029 strongly inhibits Tyk2 phosphorylation, implicating both JAK2 and Tyk2 as upstream requirements for IL-23-induced IL-23R expression[2].
Cell Proliferation Assay[1] | Cell Line: | OVCAR8TRovarian cancer cells | | Concentration: | 5 and 10 μM | | Incubation Time: | 24 hours | | Result: | Down-regulated cell proliferation, and induced apoptotic cell death.
Treatment resulted in a marked, 20-fold induction of apoptosis in the OVCAR8TRcells that express constitutively activated Stat3. |
Western Blot Analysis[1] | Cell Line: | MDA-MB-468 and MDA435 (breast cancer), OV1063 (ovarian cancer), and the paclitaxel-resistant ovarian cancer daughter lines, SKOV-3TRand OVCAR8TR. | | Concentration: | 10 μM | | Incubation Time: | 24 hours | | Result: | Led to reduced levels of pStat3. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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