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Reticuline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Reticuline图片
CAS NO:485-19-8
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品名称
番荔枝碱
产品介绍
Reticuline 通过JAK2/STAT3NF-κB信号通路显示抗炎作用。Reticuline 还可抑制 TNF-α 和 IL-6 的 mRNA 表达,并降低 JAK2 和 STAT3 的磷酸化水平。Reticuline 具有心血管作用。
生物活性

Reticuline shows anti-inflammatory effects throughJAK2/STAT3andNF-κBsignaling pathways. Reticuline inhibits mRNA expressions of TNF-α, andIL-6and reduces the phosphorylation levels ofJAK2andSTAT3[1]. Reticuline exhibits cardiovascular effects[2].

IC50& Target

JAK2

 

STAT3

 

NF-κB

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) inhibits in a concentration-dependent manner the contractions induced by Phenylephrine (1 μM), KCl (80 mM) and KCl (30 mM), (IC50=40±10, 240±40 and 300±40 μM, respectively) in isolated rat aortic rings with intact endothelium[2].
Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) antagonizes CaCl2-induced contractions, and also inhibits the intracellular calcium dependent transient contractions induced by Norepinephrine (1μM), but not those induced by Caffeine (20 mM)[2].

体内研究
(In Vivo)

Reticuline (5, 10 and 20 mg/kg, i. v., randomly) injections produced an intense hypotension in normotensive rats. The hypotensive effect of Reticuline is probably due to a peripheral vasodilation in consequence of: 1) muscarinic stimulation and NOS activation in the vascular endothelium, 2) voltage-dependent Ca2+channel blockade and/or 3) inhibition of Ca2+release from norepinephrine-sensitive intracellular stores[2].

分子量

329.39

性状

Solid

Formula

C19H23NO4

CAS 号

485-19-8

中文名称

番荔枝碱;牛心果碱

结构分类
  • Alkaloids
  • Isoquinoline Alkaloids
  • Phenols
  • Polyphenols
来源
  • Plants
  • Lauraceae
  • Lindera aggregata(Sims) Kosterm.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month