TyK2-IN-2 (Compoud 18) is a potent and selectiveTYK2inhibitor withIC₅₀s of 7 nM, 0.1 μM and 0.05 μM forTYK2JH2,IL-23andIFNα, respectively. TyK2-IN-2 also inhibitsphosphodiesterase4 (PDE4)with anIC₅₀of 62 nM. TyK2-IN-2 can be used for the research of inflammatory and autoimmune diseases^[1].

A co-crystal structure of TyK2-IN-2 (Compoud 18) bound to the TYK2 JH2 is solved. First, limited room between C8 and the hinge is seen, consistent with the loss in affinity seen with groups larger than methylamino at this position. There are also hydrogen bonds revealed between the NH of the C8 methylamine and from N1 of the IZP core to the ‘hinge’ (Val690). Additional hydrogen bonds are observed from the oxygen of the C3 amide to Lys642 and to the hinge carbonyl of Glu688 through a bridging water molecule. The pocket proximal to the C3 amide of the TYK2 JH2 domain contains a combination of residues which are largely unique relative to the kinome such as a small residue (Ala671) under the “gatekeeper” (Thr687) and the replacement of the highly kinase-conserved DFG motif by DPG which alters the positioning of the conserved catalytic Lys642 and Asp759. The ability of the C3 amide to fit and bind to this pocket is believed to be a key source of kinome selectivity for TyK2-IN-2 (Compoud 18)^[1].

310.35

Solid

C₁₆H₁₈N₆O

2098466-94-3

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 25 mg/mL(80.55 mM)

*"≥" means soluble, but saturation unknown.

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