Filgotinib-d4 (GLPG0634-d4) is the deuterium labeled Filgotinib. Filgotinib (GLPG0634) is a selectiveJAK1inhibitor withIC₅₀of 10 nM, 28 nM, 810 nM, and 116 nM forJAK1,JAK2,JAK3, andTYK2, respectively.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

429.53

C₂₁H₁₉D₄N₅O₃S

2041095-50-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.