PF-06726304 acetate

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PF-06726304 acetate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2080306-28-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PF-06726304 acetate 是一种有效的选择性EZH2抑制剂。PF-06726304 acetate 抑制野生型和 Y641N 突变型 EZH2，K_i分别为 0.7 和 3.0 nM。PF-06726304 acetate 具有强效的抗肿瘤生长活性。

生物活性

PF-06726304 acetate is a potent and selectiveEZH2inhibitor. PF-06726304 acetate inhibits wild-type and Y641N mutantEZH2withK_is of 0.7 and 3.0 nM, respectively. PF-06726304 acetate displays robust antitumor growth activity^[1].

IC₅₀& Target^[1]

EZH2 WT

0.7 nM (Ki)

EZH2 Y641N

3.0 nM (Ki)

体外研究
(In Vitro)

PF-06726304 (Compound 31) inhibits H3K27me3 in Karpas-422 with an IC₅₀of 15 nM^[1].
PF-06726304 inhibits the proliferation of Karpas-422 cells that harbor wild-type EZH2 with an IC₅₀of 25 nM^[1].

体内研究
(In Vivo)

PF-06726304 (200 and 300 mg/kg; BID for 20 days) inhibits tumor growth and induces robust modulation of downstream biomarkers in a subcutaneous Karpas-422 xenograft model^[1].

Animal Model:	Female Scid beige mice (6-8 weeks old) with Karpas-422 xenograft model^[1]
Dosage:	200 and 300 mg/kg
Administration:	Given BID for 20 days
Result:	Inhibited tumor growth and induced robust modulation of downstream biomarkers in a subcutaneous Karpas-422 xenograft model.

分子量

506.38

Formula

C₂₄H₂₅Cl₂N₃O₅

CAS 号

2080306-28-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.