Dot1L-IN-1 TFA is a highly potent and selectiveDot1Linhibitor with aK_iof 2 pM and anIC₅₀of<0.1 nM. Dot1L-IN-1 TFA potently suppresses H3K79 dimethylation (IC₅₀=3 nM), as well as the activity of the HoxA9 promoter (IC₅₀=17 nM) in HeLa and Molm-13 cells, respectively^[1].

Dot1L-IN-1 (analogue 7) TFA effectively inhibits proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC₅₀=5 nM)^[1].

760.23

Solid

C₃₄H₃₇ClF₃N₉O₄S

Room temperature in continental US; may vary elsewhere.

DMSO : 50 mg/mL(65.77 mM;Need ultrasonic)

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