CM-579 is a first-in-class reversible, dual inhibitor ofG9aandDNMT, withIC₅₀values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potentin vitrocellular activity in a wide range ofcancercells^[1].

The K_dof CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC₅₀s of 92 nM and 1000 nM, respectively^[1].

492.65

C₂₉H₄₀N₄O₃

1846570-40-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.