AMPK activator 10 是一种具有口服活性的AMPK激活剂，通过细胞 ELISA 检测，EC150为 44.3 nM。AMPK activator 10 增加 ACC 的磷酸化水平。AMPK activator 10 具有降糖作用。
| 生物活性 | AMPK activator10 is an orally active, potentAMPKactivator withEC150of 44.3 nM by cell-ELISA.AMPK activator10 increases the phosphorylation levels of ACC.AMPK activator10 exhibits a glucose lowering effect[1]. |
| IC50& Target[1] | |
体内研究
(In Vivo) | AMPK activator 10 (化合物14d; 0.3, 1, 3 mg/kg; 口服灌胃; 一天2次; 21 天) 表现出降糖作用[1]。
AMPK activator 10 (0.06, 0.19, 0.56, 1.67, 5 mg/kg; 口服灌胃; 单剂量) 以剂量依赖性方式导致 ACC 的磷酸化水平升高，ACC 是 AMPK 的下游靶分子[1]。
AMPK activator 10 (0.5 mg/kg 静脉注射或 1.0 mg/kg 口服灌胃) 在大鼠中的 CL 为 9.02 mL/minokg，Cmax为 65.4 ng/mL，AUC 为 347 ng oh/mL[1]。
| Animal Model: | KKAy mice[1] | | Dosage: | 0.3, 1, 3 mg/kg | | Administration: | Orally; bid; for 21 days | | Result: | Exhibited a glucose lowering effect.
The increase in hemoglobin A1c (ΔHbA1c) between day 0 and day 21 was dose-dependently suppressed in the 14d dosed group. |
| Animal Model: | Rats[1] | | Dosage: | 0.5 mg/kg by iv or 1.0 mg/kg by po | | Administration: | IV or po | | Result: | Had a CL of 9.02 mL/minokg, a Cmaxof 65.4 ng/mL and an AUC of 347 ngoh/mL. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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