CRT0066854 hydrochloride is a potent and selective atypicalPKCs inhibitor. CRT0066854 is against full-length (FL)PKCι,PKCζ, andROCK-IIkinases withIC₅₀values of 132 nM, 639 nM, and 620 nM, respectively^[1].

CRT0066854 hydrochloride displaces a crucial Asn-Phe-Asp motif that is part of the adenosine-binding pocket and engages an acidic patch used by arginine-rich PKC substrates^[1].
CRT0066854 hydrochloride (0.2-1.2 μM; 6 days) is able to restore polarized morphogenesis in the dysplastic H-Ras spheroids, and the maximal proportion of spheroids with PSALs is at the lower dose of 1.2 μM^[1].

452.01

C₂₄H₂₆ClN₅S

2250019-91-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.