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Vincristine-d3-ester sulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vincristine-d3-ester sulfate图片
CAS NO:1217854-24-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品名称
Leurocristine-d3-ester sulfate
NSC-67574-d3-ester sulfate
22-Oxovincaleukoblastine-d3-ester sulfate
产品介绍
Vincristine-d3-ester (Leurocristine-d3-ester) sulfate 是 Vincristine sulfate 的氘代物。Vincristine sulfate是一种抗肿瘤长春花生物碱,抑制有丝分裂纺锤体中的microtubule形成,导致中期阶段的分裂细胞停滞。 它与microtubule结合的Ki为85 nM。
生物活性

Vincristine-d3-ester (Leurocristine-d3-ester) sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate is an antitumor vinca alkaloid which inhibitsmicrotubuleformation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage. It binds tomicrotubulewith aKiof 85 nM[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

926.05

性状

Solid

Formula

C46H55D3N4O14S

CAS 号

1217854-24-4

中文名称

硫酸长春新碱 ester (硫酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)