Docetaxel-d9 (RP-56976-d9) is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is amicrotubule depolymerizationinhibitor, with anIC₅₀of 0.2 μM. Docetaxel attenuates the effects of bcl-2andbcl-xLgene expression. Docetaxel arrests the cell cycle at G2/M and leads to cellapoptosis. Docetaxel has anti-cancer activity^[1][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

816.93

Solid

C₄₃H₄₄D₉NO₁₄

940867-25-4

多西他赛 d9

Room temperature in continental US; may vary elsewhere.