RGD peptide(GRGDNP)

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RGD peptide(GRGDNP)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

114681-65-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

RGD peptide (GRGDNP) 是整合素-配体相互作用的抑制剂。RGD peptide (GRGDNP) 竞争性抑制 α5β1 与细胞外基质 (ECM) 的结合。RGD peptide (GRGDNP) 通过激活增强 pro-caspase-3 激活和自动加工的构象变化来促进细胞凋亡。RGD peptide (GRGDNP) 在细胞粘附、迁移、生长和分化中起重要作用。

生物活性

RGD peptide (GRGDNP) is an inhibitor ofintegrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibitsα5β1binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotesapoptosisthrough activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation^[1]^[2]^[3].

IC₅₀& Target^[2]

α5β1

体外研究
(In Vitro)

RGD peptide (GRGDNP) (50 μM ; preincubation for 3 hours before stretch) abolishes stretch-induced IKK activation and IL-6 mRNA expression. It shows little effect on the IKK activity and IL-6 mRNA expression in unstretched HUVECs^[2].
RGD peptide (GRGDNP) (300 μg/mL; for 6 hours) completely reverses enhanced FN1 expression in oxygen glucose deprivation(OGD) treated primary hippocampal neurons, HT22 cell lines and in its sEVs^[3].

分子量

614.61

Formula

C₂₃H₃₈N₁₀O₁₀

CAS 号

114681-65-1

Sequence

Gly-Arg-Gly-Asp-Asn-Pro

Sequence Shortening

GRGDNP

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.