K34c 是一种有效的、选择性α5β1 integrin拮抗剂。 K34c 可用于胶质母细胞瘤研究。
| 生物活性 | K34c is a potent and selectiveα5β1integrinantagonist. K34c can be used for glioblastoma research[1]. |
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体外研究
(In Vitro) | K34c (20 μM; 24 or 48 h) significantly induces U87MG cells apoptosis in combination with 1 μMEllipticine(HY-15753)[1].
K34c (20 μM; 48 h) decreases significantlyTemozolomide(HY-17364)-induced senescence in cells transfected with control non targeting siRNA without affecting significantly the residual senescence of cells transfected with siRNA specific for p53[1].
K34c (20 μM; 24 h) modulates the p53 pathway.
Apoptosis Analysis[1] | Cell Line: | U87MG cells | | Concentration: | 20 μM | | Incubation Time: | 24 or 48 h | | Result: | Induced apoptosis, led to a significant increase in apoptotic cell death measured by the population of sub-G1 cells in combination with 1 μMEllipticine(HY-15753). |
Western Blot Analysis[1] | Cell Line: | U87MG cells | | Concentration: | 20 μM | | Incubation Time: | 24 h | | Result: | DecreasedEllipticine(HY-15753)- andTemozolomide(HY-17364)-induced activation of p53. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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