Echistatin

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Echistatin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

154303-05-6

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品介绍

Echistatin 最初是来自蛇毒崩素家族中最小的 RGD 活性蛋白，是一种有效的血小板聚集的抑制剂。Echistatin 是体外骨吸收的有效抑制剂。Echistatin 是有效的α_IIbβ₃、α_vβ₃和α₅β₁的拮抗剂。

生物活性

Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor ofplatelet aggregation. Echistatin is a potent inhibitor ofbone resorptionin culture. Echistatin is a potent antagonist ofα_IIbβ₃,α_vβ₃andα₅β₁^[1]^[2]^[3]^[4].

IC₅₀& Target^[4]

αvβ3

α5β1

αIIbβ3

分子量

5417.00

Formula

C₂₁₇H₃₄₁N₇₁O₇₄S₉

CAS 号

154303-05-6

Sequence Shortening

ECESGPCCRNCKFLKEGTICKRARGDDMDDYCNGKTCDCPRNPHKGPAT (Disulfide bridge:Cys2-Cys11;Cys7-Cys32;Cys8-Cys37;Cys20-Cys39)

结构分类

Others

来源

snake Echis carinatus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.