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GSK2850163 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK2850163 hydrochloride图片
CAS NO:2319838-09-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
GSK2850163 hydrochloride 是一个新型的肌醇需要酶-1α (IRE1α) 抑制剂,它可抑制 IRE1α 的激酶活性和 RNA 酶活性,其IC50值分别为 20 和 200 nM。
生物活性

GSK2850163 hydrochloride is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibitIRE1α kinase activityandRNase activitywithIC50s of 20 and 200 nM, respectively.

IC50& Target

IC50: 20 nM (IRE1α kinase activity), 200 nM (IRE1α RNase activity)[1]

体外研究
(In Vitro)

GSK2850163 hydrochloride is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. The increased autophosphorylation of IRE1α can be reduced in a dose-dependent manner by GSK2850163 hydrochloride. Increasing concentrations of GSK2850163 hydrochloride are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163 hydrochloride: Ron (IC50=4.4 μM) and FGFR1 V561M (IC50=17 μM)[1].

分子量

482.87

Formula

C24H30Cl3N3O

CAS 号

2319838-09-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.