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Sunitinib-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sunitinib-d4图片
CAS NO:1126721-79-6
包装与价格:
包装价格(元)
2.5mg电议
1mg电议
25mg电议

产品名称
舒尼替尼 d4
产品介绍
Sunitinib-d4 (SU 11248-d4) 是 Sunitinib 的氘代物。Sunitinib (SU 11248) 是一种多靶点受体酪氨酸激酶抑制剂,抑制VEGFR2PDGFRβIC50分别为 80 nM 和 2 nM。Sunitinib 是ATP 竞争性抑制剂,可通过抑制自身磷酸化和随后的 RNase 激活来有效抑制Ire1α的磷酸化。
生物活性

Sunitinib-d4 (SU 11248-d4) is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor withIC50s of 80 nM and 2 nM forVEGFR2andPDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation ofIre1αby inhibiting autophosphorylation and consequent RNase activation[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

402.50

Formula

C22H23D4FN4O2

CAS 号

1126721-79-6

中文名称

舒尼替尼 d4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.