CAS NO: | 1450642-92-8 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Cemdomespib (KU-596) is a highly bioavailable second-generationHsp90modulator. Cemdomespib has shown efficacy in improving sensory deficits in models of diabetic peripheral neuropathy. Cemdomespib inducesHsp70levels and manifest neuroprotective activity through induction of the heat shock response[1][2][3]. | ||||||||
IC50& Target[1] |
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体内研究 (In Vivo) | After 8 weeks of diabetes, Cemdomespib (KU-596; 2, 10, or 20 mg/kg ; i.p.; administered for 6 weeks via a once per week) dose-dependently reverses the pre-existing psychosensory deficits. Cemdomespib also dose-dependently prevents the diabetes-induced deficits in motor (MNCV) and sensory (SNCV) nerve conduction velocities[1].
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分子量 | 447.50 | ||||||||
Formula | C24H30FNO6 | ||||||||
CAS 号 | 1450642-92-8 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. | ||||||||
溶解性数据 | In Vivo:
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