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Cemdomespib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cemdomespib图片
CAS NO:1450642-92-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
KU-596
产品介绍
Cemdomespib (KU-596) 是一种高效的二代Hsp90调节剂。Cemdomespib 具有改善糖尿病周围神经病变模型感觉缺陷的功效。Cemdomespib 通过诱导热休克反应诱导 Hsp70 水平并表现出神经保护活性。
生物活性

Cemdomespib (KU-596) is a highly bioavailable second-generationHsp90modulator. Cemdomespib has shown efficacy in improving sensory deficits in models of diabetic peripheral neuropathy. Cemdomespib inducesHsp70levels and manifest neuroprotective activity through induction of the heat shock response[1][2][3].

IC50& Target[1]

HSP90

 

体内研究
(In Vivo)

After 8 weeks of diabetes, Cemdomespib (KU-596; 2, 10, or 20 mg/kg ; i.p.; administered for 6 weeks via a once per week) dose-dependently reverses the pre-existing psychosensory deficits. Cemdomespib also dose-dependently prevents the diabetes-induced deficits in motor (MNCV) and sensory (SNCV) nerve conduction velocities[1].
Cemdomespib (20 mg/kg; oral gavage once per week for 4 weeks) significantly reverses the sensory hypoalgesia in WT mice but not the Hsp70 KO mice[1].

Animal Model:Diabetic Swiss Webster mice[1]
Dosage:2, 10, or 20 mg/kg
Administration:Administered after 8 weeks of diabetes via once per week intra-peritoneal injections.
Result:Improved diabetes induced hypoalgesia and sensory neuron bioenergetic deficits in a dose-dependent manner.
分子量

447.50

Formula

C24H30FNO6

CAS 号

1450642-92-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vivo:
  • 1.

    Cemdomespib (KU-596) is prepared in 0.1 M Captisol (β-cyclodextrin sulfobutylethers)[1].