您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > 4'-O-methyl Quercetin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
4'-O-methyl Quercetin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4'-O-methyl Quercetin图片
CAS NO:603-61-2
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
4'-O-methyl Quercetin (4'-O-Methyl Quercetin) 是槲皮素的天然类黄酮衍生物,具有抗氧化和抗炎作用。
Cas No.603-61-2
别名柽柳黄素,4'-O-Methyl Quercetin
Canonical SMILESOC1=CC(O)=C(C(C(O)=C(C2=CC=C(OC)C(O)=C2)O3)=O)C3=C1
分子式C16H12O7
分子量316.3
溶解度DMSO: Slightly Soluble,Methanol: Slightly Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4'-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4'-O-methyl Quercetin is a major metabolite of quercetin that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC50 values ranging from 5.5-24.1 μM. It induces G2-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4'-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC50 = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy. 4'-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC50 = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).