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12-oxo Leukotriene B4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
12-oxo Leukotriene B4图片
CAS NO:136696-10-1
包装与价格:
包装价格(元)
10μg电议
25μg电议
50μg电议
100μg电议

产品介绍
Cas No.136696-10-1
Canonical SMILESCCCCC/C=C\CC(=O)\C=C/C=C\C=C\[C@@H](O)CCCC(=O)O
分子式C20H30O4
分子量334.4
溶解度DMF: Miscible,DMSO: Miscible,Ethanol: Miscible,PBS (pH 7.2): >1 mg/ml
储存条件Store at -80°C,protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give 10,11-dihydro-LTB4. 12-oxo-LTB4 (EC50 = 33 nM) is about 70-fold less potent than LTB4 (EC50 = 0.46 nM) at stimulating Ca2+ mobilization in human neutrophils. It is also significantly less potent than LTB4 at stimulating neutrophil migration with EC50 values of 170 and 2.7 nM for 12-oxo-LTB4 and LTB4, respectively.