您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > NCC-149
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
NCC-149
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NCC-149图片
CAS NO:1316652-41-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
NCC-149 是一种选择性的HDAC8抑制剂,可用于神经分化研究。
生物活性

NCC-149 is a selectiveHDAC8inhibitor and can be used for neural differentiation research[1].

IC50& Target

HDAC8

 

体外研究
(In Vitro)

NCC-149 (5 μM; 3 days) remarkably reduces NeuN expression levels in P19 cells[1].
NCC-149 (0-40 μM; 4 days) reduces embryoid body size in a dose-dependent manner[1].
NCC-149 (5 and 20 μM; 24 h) downregulates P19 cell proliferation[1].
NCC-149 (2.5 and 5 μM; 24 h) leads to cell growth retardation by G2/M phase arrest[1].

Western Blot Analysis[1]

Cell Line:P19 cells
Concentration:5 μM
Incubation Time:3 days
Result:Remarkably reduced NeuN expression levels.

Cell Proliferation Assay[1]

Cell Line:P19 cells
Concentration:5 and 20 μM
Incubation Time:24 h
Result:Downregulated cell proliferation.

Cell Cycle Analysis[1]

Cell Line:P19 cells
Concentration:2.5 and 5 μM
Incubation Time:24 h
Result:Led to a significant increase in G2/M phase cells, with a slight decrease in S phase cells.

RT-PCR[1]

Cell Line:P19 cells
Concentration:25 μM or 2.5 and 5 μM
Incubation Time:4 days (25 μM) or 48 h (2.5 and 5 μM)
Result:Did not reduce the HDAC8 expression at the mRNA level.
Significantly and partially reduced cyclin B1 and cyclin A2 gene expression, respectively.
分子量

326.37

Formula

C16H14N4O2S

CAS 号

1316652-41-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.