HDAC6-IN-11

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HDAC6-IN-11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2409072-27-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

HDAC6-IN-11 (Compound 9) 是一种选择性的HDAC6抑制剂，IC₅₀为 20.7 nM，比对其他HDAC 异构体有超过 300 倍的选择性。HDAC6-IN-11 对癌细胞表现出抗增殖活性。

生物活性

HDAC6-IN-11 (Compound 9) is a selectiveHDAC6inhibitor with theIC₅₀value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity overHDACother isoforms. HDAC6-IN-11 shows anti-proliferative activities againstcancercells^[1].

IC₅₀& Target

HDAC6

20.7 nM (IC₅₀)

HDAC8

7750 nM (IC₅₀)

体外研究
(In Vitro)

HDAC6-IN-11 (0.44-6.68 μM, 48 h) treatment shows anti-proliferative activities against A549 and HCT116 cells^[1].
HDAC6-IN-11 (0-20 μM, 48 h) treatment can increase the acetylation status of H3 and tubulin^[1].

Cell Proliferation Assay^[1]

Cell Line:	A549 and HCT116 cells
Concentration:	0.44-6.68 μM
Incubation Time:	48 hours
Result:	Showed anti-proliferative activities to A549 and HCT116 cells (GI₅₀=3.2 and 1.82 μM, respectively).

Western Blot Analysis^[1]

Cell Line:	HCT116 cells
Concentration:	0, 0.6, 1.25, 2.5, 5, 10 and 20 μM
Incubation Time:	48 hours
Result:	Led to the increase of acetylation status of H3 and tubulin in a dose-dependent manner, and upregulated acetylated tubulin.

分子量

336.34

Formula

C₁₉H₁₆N₂O₄

CAS 号

2409072-27-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.