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PDE5/HDAC-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PDE5/HDAC-IN-1图片
CAS NO:2414921-48-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PDE5/HDAC-IN-1 (Compound 26) 是一种有效的磷酸二酯酶 5 (PDE5)和HDAC抑制剂,IC50分别为 46.3 nM 和 14.5 nM。PDE5/HDAC-IN-1 诱导细胞凋亡(apoptosis),具有抗癌活性。
生物活性

PDE5/HDAC-IN-1 (Compound 26) is a potentphosphodiesterase5 (PDE5)andHDACinhibitor withIC50values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cellapoptosisand shows anticancer activities[1].

IC50& Target

PDE5

46.3 nM (IC50)

HDAC1

2.45 μM (IC50)

HDAC6

0.11 μM (IC50)

HDAC8

0.12 μM (IC50)

体外研究
(In Vitro)

PDE5/HDAC-IN-1 (Compound 26) shows growth inhibition with IC50values of 12.35, 7.19 and 11.79 μM against HT-29, HCT-116 and SW-620 cells, respectively[1].
PDE5/HDAC-IN-1 shows cytotoxic activity with IC50values of 1.9, 1.5, 2.5, 5.5, 9.8, 18.6, 2 and 28.2 μM against Molt 4, Sup-T1, K562, AGS, PC-3, LNCaP, T47D and CCD966SK, respectively[1].

分子量

553.45

Formula

C27H29BrN4O4

CAS 号

2414921-48-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.