HD-TAC7 is a potentPROTACHDACdegrader withIC₅₀values of 3.6 μM, 4.2 μM and 1.1 μM forHDAC1,HDAC2andHDAC3, respectively. HD-TAC7 can decreasesNF-κBp65 in RAW 264.7 macrophages. HD-TAC7 can be used for the research of inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD)^[1].

HD-TAC7 (10 μM; 24 hours) induces an increase of H3K27 acetylation in RAW 264.7 macrophages^[1].
HD-TAC7 (10 μM; 2-48 hours) induces HDAC3 degradation reaching the maximal effect at 6h and lasted at least 48h^[1].
HD-TAC7 (1 and 10 μM; 24 hours) downregulates NF-κB p65 in LPS-treated RAW 264.7 macrophages^[1].

657.65

C₃₃H₃₂FN₇O₇

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.