Snail/HDAC-IN-1 is a potentSnail/HDACdual target inhibitor. Snail/HDAC-IN-1 displays potent inhibitory activity againstHDAC1with an IC₅₀of 0.405 μM and potent inhibition against Snail with a K_dof 0.18 μM. Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cellapoptosis^[1].

Snail/HDAC-IN-1 (compound 9n) shows antiproliferative activity in HCT-116 cell lines with an IC₅₀of 0.0751 μM. Snail/HDAC-IN-1 shows a good inhibitory effect on NCI–H522 (GI₅₀=0.0488 μM), MDA-MB-435 (GI₅₀=0.0361 μM), and MCF7 (GI₅₀=0.0518 μM)^[1].

488.54

C₂₄H₂₁FN₈OS

2415281-52-4

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