KH-259 (compound 1) is a potent, selective and CNS-penetrantHDAC6inhibitor, with anIC₅₀of 0.26 μM. KH-259 has antidepressant effects in mice through the inhibition ofHDAC6in the brain. KH-259 can be used for neurodegenerative diseases research^[1].

KH-259 (compound 1) exhibits acceptable metabolic stability in both mouse and human liver microsomes^[1].

KH-259 (compound 1) (10 mg/kg, IP, once) in mice significantly increases acetylated α-tubulin levels without increasing acetylated histone H3K9 levels in the brain, indicating that KH-259 has antidepressant effects in mice through the inhibition of HDAC6 in the brain^[1].

339.43

C₂₀H₂₅N₃O₂

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.