HDAC6-IN-10

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HDAC6-IN-10

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2408286-73-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

HDAC6-IN-10 是一种高选择性的HDAC6抑制剂，IC₅₀为 0.73 nM，对其他 HDAC 异构体有 144~10941 倍的选择性。HDAC6-IN-10 对多发性骨髓瘤细胞表现出抗增殖活性。

生物活性

HDAC6-IN-10 is a highly selectiveHDAC6inhibitor with theIC₅₀of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over otherHDACisoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells^[1].

IC₅₀& Target^[1]

HDAC6

0.73 nM (IC₅₀)

HDAC10

105 nM (IC₅₀)

HDAC8

513 nM (IC₅₀)

HDAC7

752 nM (IC₅₀)

HDAC11

1800 nM (IC₅₀)

HDAC9

2560 nM (IC₅₀)

HDAC5

4370 nM (IC₅₀)

HDAC4

5620 nM (IC₅₀)

HDAC1

8020 nM (IC₅₀)

体外研究
(In Vitro)

HDAC6-IN-10 (Compound 21b) (0.1-10 μM; 24 h) treatment shows highly selective inhibition against HDAC6^[1].
HDAC6-IN-10 (Compound 21b) (0-100 μM; 72 h) treatment shows anti-proliferative activities against two multiple myeloma cells RPMI-8226 and U266^[1].

Western Blot Analysis^[1]

Cell Line:	HCT-116
Concentration:	0.1, 1 and 10 μM
Incubation Time:	24 hours
Result:	Showed a dose-dependent increase in the level of Ac-tubulin.

Cell Proliferation Assay^[1]

Cell Line:	RPMI-8226 and U266 cells
Concentration:	0-100 μM
Incubation Time:	72 hours
Result:	Showed antiproliferative activities against RPMI-8226 and U266 with the IC₅₀s of 33.183 μM and 43.233 μM, respectively.

分子量

392.41

Formula

C₂₁H₂₀N₄O₄

CAS 号

2408286-73-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.