HDAC6-IN-5

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HDAC6-IN-5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2413603-15-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

HDAC6-IN-5 (化合物 11b) 是一种有效的透过血脑屏障的HDAC6抑制剂，其IC₅₀为0.025 μM。HDAC6-IN-5 对Aβ_1-42自聚集和AChE表现出较强的抑制活性，IC₅₀值分别为 1.1 和 0.88 μM。HDAC6-IN-5 可促进神经突起生长，且无明显神经毒性。

生物活性

HDAC6-IN-5 (compound 11b) is a potent and BBB-penetratedHDAC6inhibitor, with anIC₅₀of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity againstAβ_1-42self-aggregation andAChE, withIC₅₀values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity^[1].

IC₅₀& Target

AChE

0.72 μM (IC₅₀)

HDAC6

0.026 ± 0. μM (IC₅₀)

HDAC1

0.09 ± 0.0 μM (IC₅₀)

HDAC

0.16 ± 0.0 μM (IC₅₀)

HDAC3

0.33 ± 0. μM (IC₅₀)

HDAC2

0.48 ± 0.0 μM (IC₅₀)

HDAC9

5.51 ± 0.0 μM (IC₅₀)

HDAC5

7.19 ± 0.4 μM (IC₅₀)

HDAC4

7.85 ± 0.6 μM (IC₅₀)

HDAC7

9.13 ± 0.3 μM (IC₅₀)

体外研究
(In Vitro)

HDAC6-IN-5 (compound 11b) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, withEC₅₀values of 0.58 and 8 μM, respectively^[1]

分子量

408.25

Formula

C₂₀H₁₄BrN₃O₂

CAS 号

2413603-15-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.