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Resminostat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Resminostat图片
CAS NO:864814-88-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
RAS2410
4SC-201
产品介绍
Resminostat (RAS2410; 4SC-201) 是一种有效的HDAC1HHDAC3HDAC6抑制剂,IC50值分别为 42.5,50.1,71.8 nM,同时对 HDAC8 有较弱的抑制作用,IC50值为 877 nM。
生物活性

Resminostat (RAS2410; 4SC-201) is a potent inhibitor ofHDAC1,HDAC3andHDAC6, with meanIC50values of 42.5, 50.1, 71.8 nM, respectively, and shows less potent activities againstHDAC8, with anIC50of 877 nM.

IC50& Target[1]

HDAC1

42.5 nM (IC50)

HDAC3

50.1 nM (IC50)

HDAC6

71.8 nM (IC50)

HDAC8

877 nM (IC50)

体外研究
(In Vitro)

Resminostat (RAS2410; 4SC-201; 5 μM) induces histone acetylation in myeloma cells. Resminostat hydrochloride displays a substrate competitive binding mode with a mean Kivalue of 27 nM. Resminostat hydrochloride (5 μM) induces histone hyperacetylation in myeloma cells. Resminostat inhibits cell growth, induces apoptosis and inhibits MM cell proliferation. Resminostat (5 μM) also modulates expression of bcl-2 family proteins and inhibits Akt pathway signalling downstream of Akt. Resminostat exerts synergistic activity against myeloma cells when combined with common and new anti-myeloma agents[1].
Resminostat inhibits cell growth in head and neck squamous cell carcinoma cell lines, with IC50s ranging from 0.775 μM to 1.572 μM (IC50for SCC25: 0.775 μM; CAL27: 1.572 μM; and FaDu: 0.899 μM). Resminostat (1.25 and 2.5 μM) has a synergistic effect with irradiation on HNSCC cell lines. Resminostat in combination with cisplatin induces a downregulation of survivin. However, Resminostat shows no effect on Mcl-1 and p-AKT expression[2].
Resminostat reduces viability of HCC cells with the co-treatment of AZD-2014, with IC50s ranging from 0.89 ± 0.12 μM to 0.07 ± 0.01 μM[3].

Clinical Trial
分子量

349.40

Formula

C16H19N3O4S

CAS 号

864814-88-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.