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QTX125
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
QTX125图片
CAS NO:1279698-31-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
QTX125 是一种有效且高度选择性的HDAC6抑制剂。与其他 HDAC 相比,QTX125 对HDAC6具有出色的选择性。QTX125 具有抗肿瘤作用。
生物活性

QTX125 is a potent and highly selectiveHDAC6inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects[1].

IC50& Target[1]

HDAC6

 

体外研究
(In Vitro)

QTX125 (25-500 nM; 24-48 hours) treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP[1].
In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin[1].
QTX125 has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL)[1].

Apoptosis Analysis[1]

Cell Line:MINO, REC-1, IRM-2 and HBL-2 cells
Concentration:25 nM, 50 nM, 100 nM, 500 nM
Incubation Time:24 hours, 48 hours
Result:Inhibited annexin V/propidium iodide double staining.

Western Blot Analysis[1]

Cell Line:MINO, REC-1, IRM-2 and HBL-2 cells
Concentration:25 nM, 50 nM, 100 nM, 500 nM
Incubation Time:24 hours
Result:Inhibited the cleavage of caspase-9, caspase-8, caspase-3, and PARP.
体内研究
(In Vivo)

QTX125 (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice[1].

Animal Model:Nude mice bearing REC-1 or MINO cells[1]
Dosage:60 mg/kg
Administration:Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
Result:Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.
分子量

417.41

Formula

C23H19N3O5

CAS 号

1279698-31-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.