QTX125

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QTX125

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1279698-31-5

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议

产品介绍

QTX125 是一种有效且高度选择性的HDAC6抑制剂。与其他 HDAC 相比，QTX125 对HDAC6具有出色的选择性。QTX125 具有抗肿瘤作用。

生物活性

QTX125 is a potent and highly selectiveHDAC6inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects^[1].

IC₅₀& Target^[1]

HDAC6

体外研究
(In Vitro)

QTX125 (25-500 nM; 24-48 hours) treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP^[1].
In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin^[1].
QTX125 has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL)^[1].

Apoptosis Analysis^[1]

Cell Line:	MINO, REC-1, IRM-2 and HBL-2 cells
Concentration:	25 nM, 50 nM, 100 nM, 500 nM
Incubation Time:	24 hours, 48 hours
Result:	Inhibited annexin V/propidium iodide double staining.

Western Blot Analysis^[1]

Cell Line:	MINO, REC-1, IRM-2 and HBL-2 cells
Concentration:	25 nM, 50 nM, 100 nM, 500 nM
Incubation Time:	24 hours
Result:	Inhibited the cleavage of caspase-9, caspase-8, caspase-3, and PARP.

体内研究
(In Vivo)

QTX125 (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice^[1].

Animal Model:	Nude mice bearing REC-1 or MINO cells^[1]
Dosage:	60 mg/kg
Administration:	Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
Result:	Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.

分子量

417.41

Formula

C₂₃H₁₉N₃O₅

CAS 号

1279698-31-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.