Pomiferin (NSC 5113) acts as an potential inhibitor ofHDAC, with anIC₅₀of 1.05 μM, and also potently inhibitsmTOR(IC₅₀, 6.2 μM).

Pomiferin is an potential inhibitor of HDAC, with an IC₅₀of 1.05 μM. Pomiferin shows cytotoxic effects on human tumor cell lines, with GI₅₀s of 1.32 ± 0.02 μM (HCT-15 cells), 2.92 ± 0.09 μM (MDA-MB-231 cells), 3.18 ± 0.05 μM (ACHN cells), 3.34 ± 0.11 μM (LOX-IMVI cells), 3.95 ± 0.05 μM (PC-3 cells), 5.14 ± 0.06 μM (NCI-H23 cells), and 123 μM (Hepatocyte cells)^[1]. Pomiferin is a highly specific mTOR inhibitor, with an IC₅₀of 6.2 μM. Pomiferin triacetate only affects two PI3Kα mutants, E542K and E545K. Pomiferin triacetate (0.3125-20 μM) stabilizes Pdcd4 from TPA-induced degradation in HEK293 cells. Pomiferin triacetate (20 μM) inhibits IGF-1-induced signaling downstream of Akt activation^[2].

Pomiferin (5, 10 and 20 mg/kg, p.o.) shows protective effects on the treatment of reperfusion injury. Pomiferin also increases SOD activities and total antioxidative capacity, and decreases malondialdehyde in rats^[3].

420.45

Solid

C₂₅H₂₄O₆

572-03-2

橙桑黄酮

• Phenols
• Polyphenols

• Plants
• Moraceae
• Maclura pomifera (Raf.) Schneid.

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