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Pomiferin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pomiferin图片
CAS NO:572-03-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
橙桑黄酮
NSC 5113
产品介绍
Pomiferin (NSC 5113) 为HDACmTOR的抑制剂,IC50值分别为 1.05 μM 和 6.2 μM。
生物活性

Pomiferin (NSC 5113) acts as an potential inhibitor ofHDAC, with anIC50of 1.05 μM, and also potently inhibitsmTOR(IC50, 6.2 μM).

IC50& Target[1][2]

HDAC

1.05 μM (IC50)

mTOR

6.2 μM (IC50)

体外研究
(In Vitro)

Pomiferin is an potential inhibitor of HDAC, with an IC50of 1.05 μM. Pomiferin shows cytotoxic effects on human tumor cell lines, with GI50s of 1.32 ± 0.02 μM (HCT-15 cells), 2.92 ± 0.09 μM (MDA-MB-231 cells), 3.18 ± 0.05 μM (ACHN cells), 3.34 ± 0.11 μM (LOX-IMVI cells), 3.95 ± 0.05 μM (PC-3 cells), 5.14 ± 0.06 μM (NCI-H23 cells), and 123 μM (Hepatocyte cells)[1]. Pomiferin is a highly specific mTOR inhibitor, with an IC50of 6.2 μM. Pomiferin triacetate only affects two PI3Kα mutants, E542K and E545K. Pomiferin triacetate (0.3125-20 μM) stabilizes Pdcd4 from TPA-induced degradation in HEK293 cells. Pomiferin triacetate (20 μM) inhibits IGF-1-induced signaling downstream of Akt activation[2].

体内研究
(In Vivo)

Pomiferin (5, 10 and 20 mg/kg, p.o.) shows protective effects on the treatment of reperfusion injury. Pomiferin also increases SOD activities and total antioxidative capacity, and decreases malondialdehyde in rats[3].

分子量

420.45

性状

Solid

Formula

C25H24O6

CAS 号

572-03-2

中文名称

橙桑黄酮

结构分类
  • Phenols
  • Polyphenols
来源
  • Plants
  • Moraceae
  • Maclura pomifera (Raf.) Schneid.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month