您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Mahanimbine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Mahanimbine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mahanimbine图片
CAS NO:21104-28-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Mahanimbine 是一种来自咖喱叶的口服活性生物碱。
Cas No.21104-28-9
别名马汉九里香碱
Canonical SMILESC/C(C)=C/CC[C@]1(C)OC2=C(C(NC3=C4C=CC=C3)=C4C=C2C)C=C1
分子式C23H25NO
分子量331.5
溶解度DMSO: 10 mM
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mahanimbine is a carbazole alkaloid that has been found inM. koenigiiand has diverse biological activities.1,2,3It is active againstS. aureusandS. pyogenes(MIC100= 50 µg/ml for both), as well asA. aegyptifourth instar larvae when used at a concentration of 100 µg/ml.1Mahanimbine induces cell cycle arrest at the G0/G1phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively).2It decreases body weight gain without affecting food intake and reduces increases in plasma total cholesterol and triglyceride levels in a rat model of high-fat diet-induced obesity when administered orally at a dose of 30 mg/kg.3

1.Ramsewak, R.S., Nair, M.G., Strasburg, G.M., et al.Biologically active carbazole alkaloids from Murraya koenigiiJ. Agric. Food Chem.47(2)444-447(1999) 2.Pei, C., He, Q., Liang, S., et al.Mahanimbine exerts anticancer effects on human pancreatic cancer cells by triggering cell cycle arrest, apoptosis, and modulation of AKT/mammalian target of rapamycin (mTOR) and signal transducer and activator of transcription 3 (STAT3) signalling pathwaysMed. Sci. Monit.246975-6983(2018) 3.Birari, R., Javia, V., and Bhutani, K.K.Antiobesity and lipid lowering effects of Murraya koenigii (L.) spreng leaves extracts and mahanimbine on high fat diet induced obese ratsFitoterapia81(8)1129-1133(2010)