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Biotin-PEG3-C3-NH2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Biotin-PEG3-C3-NH2图片
CAS NO:183896-00-6
包装:100mg
市场价:1305元

产品介绍
Biotin-PEG3-C3-NH2 是一种 PROTAC linker，属于PEG 类，具有 NH2 官能团。可用于合成 PROTAC 分子。
Cas No.183896-00-6
分子式C20H38N4O5S
分子量446.6
储存条件Store at -20°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Biotin-PEG3-C3-NH2 is a PEG-basedPROTAClinker, with NH2functional group, that can be used in the synthesis ofPROTACs[1].

PROTAC linkers exert function for connecting the two different ligands that make up PROTACs, the two ligands are E3 ubiquitin ligase and the target protein, respectively[1].
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
PROTAC can significantly attenuate tumor progression in tumor xenografts[1].
Biotin-PEG3-C3-NH2 (compound 11) (0-2 mM; 3 h) combinded with protein G (compound 6) displays fluorescence under streptavidin probes, Biotin-PEG3-C3-NH2 is a powerful tool for the high-throughput analysis of protein-small molecule interaction and profiling enzyme activities in a microarrays constructed by surface derivatization method[3].