CAS NO: | 1808113-09-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Corin is a dual inhibitor of histone lysine specific demethylase(LSD1)and histone deacetylase(HDAC), with aKi(inact)of 110 nM for LSD1 and anIC50of 147 nM forHDAC1. | ||||||||||||||||
IC50& Target | IC50: 147 nM (HDAC1), Ki(inact): 110 nM (LSD1)[1]. | ||||||||||||||||
体外研究 (In Vitro) | Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC5095 nM vs. MS-275 EC50420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM)[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 428.53 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C26H28N4O2 | ||||||||||||||||
CAS 号 | 1808113-09-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(233.36 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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