CAS NO: | 74832-57-8 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Fludarabine triphosphate (F-ara-ATP), the active metabolite ofFludarabine(HY-B0069), is a potent, noncompetitive and specific inhibitor ofDNA primase, with anIC50of 2.3 μM and aKiof 6.1 μM. Fludarabine triphosphate inhibitsDNA synthesisby blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellularapoptosis[1][2]. |
IC50& Target | IC50: 2.3 ± 0.3 μM (DNA primase); Ki: 6.1 ± 0.3 μM (DNA primase)[1] |
体外研究 (In Vitro) | Fludarabine triphosphate is a more potent inhibitor of the polydeoxythymidylate primase activity than of the DNA polymerase α/δ activities present in the supernatants of CCRF-CEM cells[1]. |
分子量 | 525.17 |
Formula | C10H15FN5O13P3 |
CAS 号 | 74832-57-8 |
中文名称 | 三磷酸氟达拉滨 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |