ZLHQ-5f is a dualCDK2andTopo Iinhibitor with anIC₅₀of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggersapoptosisin HCT116 cells, and has a good safety profile^[1].

ZLHQ-5f shows antiproliferative activity with GI₅₀values of 0.949 ± 0.113, 0.821 ± 0.240, 1.124 ± 0.362, 1.945 ± 0.278 and 3.349 ± 0.149 μM against A549, HCT116, MCF-7, HepG2 and LO2 cells, respectively^[1].

463.53

C₂₈H₂₅N₅O₂

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.