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RJR-2403 oxalate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
RJR-2403 oxalate图片
CAS NO:220662-95-3
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
RJR-2403 oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) 是一种神经元烟碱受体激动剂，对 α4β2 亚型 (Ki=26 nM) 具有高选择性； >1,000 倍的选择性比 α7 受体（Ki = 3.6 μM）。
Cas No.220662-95-3
别名(3E)-N-甲基-4-(3-吡啶基)-3-丁烯-1-胺草酸盐,(E)-Metanicotine oxalate; Rivanicline oxalate; RJR 2403 oxalate
化学名(E)-N-methyl-4-pyridin-3-ylbut-3-en-1-amine;oxalic acid
Canonical SMILESCNCCC=CC1=CN=CC=C1.C(=O)(C(=O)O)O
分子式C12H16N2O4
分子量252.27
溶解度Soluble to 100 mM in sterile water
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Rivanicline oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); >1,000 fold selectivity than α7 receptors(Ki= 3.6 μM).

References:
[1]. Bencherif M, et al. RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21.
[2]. Lippiello PM, et al. RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9.
[3]. Damaj MI, et al. Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8.