CDK6/9-IN-1 (compound 66) is an orally active active and dualCDK6andCDK9inhibitor, withIC₅₀values of 40.5 nM and 39.5 nM forCDK6anmdCDK9, respectively^[1].

CDK6/9-IN-1 (compound 66, 4 or 8 μM in MDA-MB-231 cells) treatment induces G0/G1 cell cycle arrest (71.85% and 77.51%, respectively), when compared with the control (57.65%)^[1].

CDK6/9-IN-1 (compound 66) significantly inhibits tumor growth in an xenograft mouse model with no obvious toxicity, indicating the promising therapeutic potential of CDK6/9 dual inhibitors for cancer treatment^[1].

452.94

C₂₂H₂₅ClN₈O

2414373-55-8

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